Raynaud's phenomenon can occur as an adverse drug reaction (ADR) to dexamphetamine. Dexamphetamine is used in the treatment of ADHD . The Netherlands Pharmacovigilance Centre Lareb received two reports describing this reaction. This ADR is not listed in the official product information (SPC) or patient information leaflet (PIL) in the EU (Amfexa®), but the US product information of dexamphetamine does warn for Raynaud's phenomenon.
Raynaud's phenomenon is a sudden discoloration of the fingers or toes due to temporary contraction of blood vessels. During an attack fingers or toes color white first, then blue, then red. Such an attack usually takes a few minutes to hours. It could be provoked due to emotion or cold, but is sometimes also due to medicines.