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Fixed drug eruption and doxycycline

Date: 16 April 2016

The Netherlands Pharmacovigilance Centre Lareb received 27 reports suspect for FDE and doxycycline. This association is supported by several case-reports in the literature. FDE will be labeled as an adverse drug reaction in the Summary of Product Characteristics of this drug.

Fixed drug eruption (FDE) is an immune-mediated mucocutaneous drug reaction, that reoccurs in the same locations upon re-exposure to the causing drug. Most often it is located on the lips, genitalia or extremities. In most cases the FDE leaves a post inflammatory hyperpigmentation after resolving.

More information regarding FDE associated with the use of doxycycline can be found here.

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