Similar reporting pattern of adverse events for homologous and heterologous COVID-19 vaccination
A high level of similarity in the local and systemic reported AEFIs (adverse events following immunization) per vaccination moment was observed. No apparent change in the type and severity of reported AEFIs were detected, with a comparable experienced burden per vaccination moment. Different vaccination sequence showed no differences in the pattern of reported AEFIs.
227.884 spontaneous reports received at The Netherlands Pharmacovigilance Centre Lareb over a period of twenty months were analyzed with the aim to describe the safety profile of monovalent COVID-19 booster vaccinations observed in the Dutch population in relation to the basic vaccination series.
Fatigue, headache and malaise were the most commonly reported AEFIs. Remarkably, a relatively high number of AEFIs regarding lymphadenopathy was reported after the third vaccination (3.67% compared to 0.53% after the first vaccination and 0.65% after the fourth vaccination). With respect to unsolicited AEFIs, the most reported AEFIs were dizziness, dyspnoea, and diarrhoea.